In 2021, a group of scientists led by researchers at the University of North Carolina at Chapel Hill, Weill Cornell Medicine and NewYork-Presbyterian reported the Moderna mRNA vaccine and a protein-based vaccine candidate containing an adjuvant, a substance that enhances immune responses. elicited robust neutralizing antibody responses to SARS-CoV-2 in infancy in preclinical studies.
A follow-up study now published by the same group Science Translation MedicineHe found that 2-dose vaccines still provided protection against lung disease in rhesus macaques one year after they were vaccinated as infants.
The paper’s co-senior authors are Kristina De Paris, PhD, professor of microbiology and immunology at the UNC School of Medicine, Sallie Permar, PhD, chair of the Department of Pediatrics at Weill Cornell Medicine, and Koen KA Van Rompay. , DVM, PhD, leader of the Infectious Diseases Unit at the California National Primate Survey at the University of California, Davis. Co-first authors are Emma C. Milligan of the UNC School of Medicine’s Child Research Institute and Katherine Olstad of the California National Primate Research Center.
To evaluate the SARS-CoV-2 vaccination of infants, the researchers vaccinated two groups of eight rhesus infants at 2 months of age and again four weeks later at the California National Primate Research Center. Each animal received one of two types of vaccines: a preclinical version of the Moderna mRNA vaccine, or a vaccine that combines a protein developed by the National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center, part of the National Institutes of Health. a potent adjuvant formulation. The adjuvant formulation of 3M molecular adjuvant 3M-052, formulated by the Access to Advanced Health Institute (AAHI) in a squalene emulsion, stimulates immune responses by activating receptors on immune cells.
Dr. said De Paris. “We found that although SARS-CoV-2 variants acquire multiple mutations in spike proteins that differ from the vaccine immunogen, both vaccines protect against lung disease.”
Dr. De Paris said that overall, the candidate for the adjuvanted protein vaccine retains higher levels of neutralizing antibodies and provides superior protection compared to the mRNA vaccine. These data imply that these vaccines are safe and highly effective when given to young macaque babies. In addition, the results provide information on the optimization and development of SARS-CoV-2 vaccines.
“With COVID-19, toddlers are one of the most vulnerable pediatric populations. This fall, SARS-CoV-2, flu, is also the Nancy C. Paduano Professor of Pediatrics at Weill Cornell Medicine and chief pediatrician at NewYork-Presbyterian Komansky Children’s Hospital. “We must seize every opportunity to provide safe and effective vaccine immunity to our youngest patients, including considering COVID-19 vaccination no earlier than 6 months of age, which is currently recommended.”
“This study highlights that human infants should be vaccinated against SARS-CoV-2 whenever possible, as the benefits are clear and long-lasting. It also highlights the value of animal models in infectious disease research.” aforementioned. “The lessons we have learned and the resources and tools developed in the current study will be invaluable for future pandemic preparedness to more effectively combat outbreaks with novel coronaviruses or other respiratory viruses in pediatric populations.”
This research was conducted by the National Institutes of Health (P01AI117915-06S1), (U54 CA260543), (P510D11107), (UM1 AI068618-15: HVTN/HPTN, CoVPN), (P30AI050410: UNC AIDS Research Center), and (P30 CA016086: UNC-LCCC) Flow Cytometry Core Facility).
Other authors are Caitlin A. Williams, Michael Mallory, Patricia Cano, Kaitlyn A. Cross, Jennifer E. Munt, Carolina Garrido, Lisa Lindesmith, Jennifer Watanabe, Jodie L. Usachenko, Lincoln Hopkins, Ramya Immareddy, Yashavanth Shaan Lakshmanappa, Sonny R’ is Elizaldi, Jamin W. Roh, Rebecca L. Sammak, JoAnn L. Yee, Savannah Herbek, Trover Scobey, Dieter Miehlke, Genevieve Fouda, Guido Ferrari, Hongmei Gao, Xiaoying Shen, Pamela A. Kozlowski, David Montefiori, Michael Hudgens, Darin K. Edwards, Andrea Carfi, Kizzmekia S. Corbett, Barney S. Graham, Christopher B. Fox, Mark Tomai, Smita S. Iyer, Ralph Baric, Rachel Reader, and Dirk P. Dittmer.