Bile acid improves metabolism of intrauterine growth retardation in piglets

Schematic diagram of bile acid metabolism in normal birth weight piglets and IUGR piglets. 1 credit

Intrauterine growth retardation (IUGR), defined as impaired growth and development of a mammalian embryo/fetus or fetal organs during pregnancy, is a major concern in pig farming. IUGR animals exhibit impaired growth and development, poor meat quality, and higher morbidity and mortality after birth. Therefore, IUGR is a major problem for the swine industry due to the lack of a comprehensive understanding of the growth regulation mechanism of IUGR piglets.

The research team of Kong Xiangfeng of the Subtropical Agriculture Institute of the Chinese Academy of Sciences systematically investigated the growth and development, body metabolism and gut microecological profiles of normal birth weight pigs and IUGR pigs at different growth stages.

Combining fecal microbial transplantation and germ-free mice, the researchers confirmed that IUGR alters the diversity and metabolic pathways of the gut microbiota, resulting in abnormal intestinal energy, amino acids and bile acid metabolism, which inhibits the subsequent growth and development of IUGR pigs. .

Administration of dietary bile acid demonstrated that bile acid supplementation could improve liver function, increase the relative abundance of potentially beneficial bacteria in the gut, and alleviate intestinal mucosal oxidative damage of IUGR piglets.

In addition, dietary bile acid supplementation can also improve colonic barrier function and redox status of IUGR piglets, which benefits intestinal health.

These findings suggest that the gut microbiota can be used as targets to regulate IUGR and that bile acids play an important role in improving IUGR metabolism and maintaining gut health in piglets.

The most recent research has been published in the journal: Journal of Animal Science and Biotechnology, Boundaries in Microbiologyand Limits in Nutrition.

More information:
W. Zhang et al. Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and differential taxonomic abundance, Journal of Applied Microbiology (2019). DOI: 10.1111/jam.14304

Liang Xiong et al., Intrauterine growth restriction alters growth performance, plasma hormones, and small intestinal microbial communities in growth-depleted pigs, Journal of Animal Science and Biotechnology (2020). DOI: 10.1186/s40104-020-00490-x

Yang Liu et al, Intrauterine growth retardation affects liver bile acid metabolism in growing pigs: effects associated with changes in colonic bile acid derivatives, Journal of Animal Science and Biotechnology (2022). DOI: 10.1186/s40104-022-00772-6

Wu Tang et al. Metabolome, microbiome and gene expression changes in the colon of neonatal piglets with intrauterine growth restriction, Boundaries in Microbiology (2022). DOI: 10.3389/fmicb.2022.989060

Yang Liu et al., Dietary bile acid supplementation alters plasma biochemical and hormone indicators, intestinal digestive capacity, and microbiota of piglets with normal birth weight and intrauterine growth retardation, Boundaries in Microbiology (2022). DOI: 10.3389/fmicb.2022.1053128

Yang Liu et al., Dietary bile acids supplementation modulates immune response, antioxidant capacity, glucose and lipid metabolism in normal and intrauterine growth retardation piglets, Limits in Nutrition (2022). DOI: 10.3389/fnut.2022.991812

Provided by the Chinese Academy of Sciences

Quotation: Bile acid ameliorates intrauterine growth retardation metabolism in piglets (2022, 30 Dec) retrieved from on 30 Dec 2022

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